With money to burn you could certainly make great strides in improving software in many areas of the sciences. A lot of tools used daily in areas of biology for

With money to burn you could certainly make great strides in improving software in many areas of the sciences. A lot of tools used daily in areas of biology for example are very capable but were typically designed for use by the original author only. You could improve the lives of countless grad students and other researchers simply by providing a decent UI and good documentation. The savings and benefits would be enormous but you certainly would not make any money doing so.