4 ms·
Is that a standard dose? Why do you take it sublingually instead of snorting it? I have taken ketamine recreationally...that is quite a high dose at least from
by temp2903d 7y ago
Is that a standard dose? Why do you take it sublingually instead of snorting it?
I have taken ketamine recreationally...that is quite a high dose at least from my experience, though I've never though to take it sublingually.
- atomical 7y agoThere isn't a standard dose. Far too early for that. I take it sublingually because that's what my doctor prescribes.
- car 7y agoDoc here. Sublingual application bypasses the liver, which removes drugs from the bloodstream. Same reason why nitro is applied here.
- behindmyscreen 7y agoThat’s interesting. What’s the mechanism for that? Uninformed intuition would lead one to think there would not be a difference.
- car 7y agoIt's a function of anatomy. The sublingual veins drain into the jugular and then vena cava. For drugs this avoids the first-pass effect, which is exploited when giving nitroglycerin for angina pectoris. Other ways to achieve this are suppositories (rectal veins) and intravenous (i.v.) or intramuscular (i.m.) injection. https://en.wikipedia.org/wiki/Lingual_veins https://en.wikipedia.org/wiki/Lingual_veins https://en.wikipedia.org/wiki/First_pass_effect https://en.wikipedia.org/wiki/First_pass_effect
- atomical 7y agoSome of the drug will always be absorbed orally and travel to the liver through the the portal vein. The liver will eventually remove ketamine from the bloodstream regardless of which route is used. That's my understanding at least.