4 ms·

I take 250mg sublingual. I put it under my tongue at night while listening to music.

MetalGuru 7y ago
Can you describe your experience with it (how resistant your depression was, how effective ket is, what the short and long term effects you’re noticing are)?
- atomical 7y ago
  I had tried several anti-depressants before ketamine. I feel a lot better and have much more energy. A side effect while taking the drug in the short term is dissociation. As tolerance builds that eventually goes away. I'm having some issues with sleep and productivity at night.
temp2903d 7y ago
Is that a standard dose? Why do you take it sublingually instead of snorting it? I have taken ketamine recreationally...that is quite a high dose at least from my experience, though I've never though to take it sublingually.
- atomical 7y ago
  There isn't a standard dose. Far too early for that. I take it sublingually because that's what my doctor prescribes.
- car 7y ago
  Doc here. Sublingual application bypasses the liver, which removes drugs from the bloodstream. Same reason why nitro is applied here.
  - behindmyscreen 7y ago
    That’s interesting. What’s the mechanism for that? Uninformed intuition would lead one to think there would not be a difference.
    - car 7y ago
      It's a function of anatomy. The sublingual veins drain into the jugular and then vena cava. For drugs this avoids the first-pass effect, which is exploited when giving nitroglycerin for angina pectoris. Other ways to achieve this are suppositories (rectal veins) and intravenous (i.v.) or intramuscular (i.m.) injection. https://en.wikipedia.org/wiki/Lingual_veins https://en.wikipedia.org/wiki/Lingual_veins https://en.wikipedia.org/wiki/First_pass_effect https://en.wikipedia.org/wiki/First_pass_effect
  - atomical 7y ago
    Some of the drug will always be absorbed orally and travel to the liver through the the portal vein. The liver will eventually remove ketamine from the bloodstream regardless of which route is used. That's my understanding at least.

Can you describe your experience with it (how resistant your depression was, how effective ket is, what the short and long term effects you’re noticing are)?

atomical 7y ago
I had tried several anti-depressants before ketamine. I feel a lot better and have much more energy. A side effect while taking the drug in the short term is dissociation. As tolerance builds that eventually goes away. I'm having some issues with sleep and productivity at night.

temp2903d 7y ago

Is that a standard dose? Why do you take it sublingually instead of snorting it? I have taken ketamine recreationally...that is quite a high dose at least from my experience, though I've never though to take it sublingually.

atomical 7y ago
There isn't a standard dose. Far too early for that. I take it sublingually because that's what my doctor prescribes.
car 7y ago
Doc here. Sublingual application bypasses the liver, which removes drugs from the bloodstream. Same reason why nitro is applied here.
- behindmyscreen 7y ago
  That’s interesting. What’s the mechanism for that? Uninformed intuition would lead one to think there would not be a difference.
  - car 7y ago
    It's a function of anatomy. The sublingual veins drain into the jugular and then vena cava. For drugs this avoids the first-pass effect, which is exploited when giving nitroglycerin for angina pectoris. Other ways to achieve this are suppositories (rectal veins) and intravenous (i.v.) or intramuscular (i.m.) injection. https://en.wikipedia.org/wiki/Lingual_veins https://en.wikipedia.org/wiki/Lingual_veins https://en.wikipedia.org/wiki/First_pass_effect https://en.wikipedia.org/wiki/First_pass_effect
- atomical 7y ago
  Some of the drug will always be absorbed orally and travel to the liver through the the portal vein. The liver will eventually remove ketamine from the bloodstream regardless of which route is used. That's my understanding at least.