> What I mean to say is, even if this were Nature, it'd be a super high-impact journal that isn't actually read by clinicians who would be best positioned to cr

> What I mean to say is, even if this were Nature, it'd be a super high-impact journal that isn't actually read by clinicians who would be best positioned to criticize the study. More importantly, the peer-reviewers are likely scientists, not physicians. This can make a subtle difference in how and what they review. But you did a great job listing out some of the shortcomings!