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Ketamine May Relieve Depression by Repairing Damaged Brain Circuits
- thatoneuser 8y agoWhat do they mean at the end by you need to maintain the new connections?
- throwaway77384 8y agoIf I've read this correctly, the theory states that depression heralds from damaged connections between synapses in a brain region regulating mood. Fixing these connections can be induced by stimulating the synapses in that area in a specific way, which Ketamine does. The effect appears to be transient, which means the damage returns after a while, requiring additional treatments. If there was a way to stop the disruption of connections in that brain region permanently, you would not need repeat Ketamine treatments.
- thatoneuser 8y agoAh so ketamine then isn't solving the problem, but rather is just repairing the damage which will come back? Kind of like road maintanence?
- ParanoidShroom 8y agoSo does Ketamine have any other ways of action besides neurogenesis? There are compounds like NSI-189 that are going towards this path, but they come up short in trails.