6 ms·

Nasa Twins Study: A multidimensional analysis of a year-long human spaceflight

105 points by miobrien 8y ago

baxtr 8y ago
Interesting that telomere length increased by 14% during flight! And, it can’t be related to a healthy lifestyle since they got shorter within 48hrs back on earth? Notably, telomere length shortened rapidly upon TW’s return to Earth, within ~48 hours [FD340 ambient return to R+0 (R+ days post return); fig. S6B] and stabilized to near preflight averages within months.
- stcredzero 7y ago
  I am not a doctor, but my understanding is that increasing telomere length could contribute to the severity of malignant tumors.
  - z3t4 7y ago
    or increase life length!? Space hypersleep might become a thing after all.
    - stcredzero 7y ago
      It's a double edged sword. Increased telomere length will not only make it easier for your normal cells to divide more, it makes it easier for cancer cells to divide more. It's actually an anti-cancer adaptation for some mammals to turn off their telomere repair.
kissickas 8y ago
> Most notably, cognitive speed decreased for all tests except for the DSST, and accuracy decreased for all domains except for spatial orientation postflight. TW’s cognitive efficiency (a combination of speed and accuracy across cognitive domains) was similar pre- and inflight relative to HR but was significantly lower postflight (P = 0.0016, Student’s t test). This postflight decline in cognitive performance persisted up to 6 months postflight in both speed and accuracy domains (Fig. 10C). This is terrifying to me. I hadn't heard of spaceflight (or the return from it) affecting cognitive function before, but they don't seem to be making it a major issue here - even after it persisted six months later. Does anyone have older sources showing the same thing? I would especially be interested in studies showing the effect over multiple flights and returns to Earth.
- scottie_m 7y ago
  It’s not a study, but it’s been hypothesized that radiation and cosmic rays could cause lasting damage of just this sort through particle showers within the brain. Truthfully though there is very little in the way of studies for the simple fact that it’s hard to set one up for astronauts. Given how radically different the environment in space is compared to Earth though, I’m not finding this surprising. I wouldn’t be surprised if it’s just the tip of a very dangerous iceberg too, and it turns out that it takes a lot of time and sacrifice to get us to live and thrive somewhere other than Earth’s surface.
  - fumar 7y ago
    We have a small sample size of humans who have been exposed to space. I wonder what human mutations will be more preferable for space travel. Physical fitness is part of the equation but so is genetic-space compatibility.
    - scottie_m 7y ago
      Agreed. Genentic engineering will probably be helpful, but first we do as you say, have to know what to engineer for. Then of course we’ll have a kind of speciation event and we’ll risk having a kind of genetic apartheid based on people who work in space vs. planetside. It could get sci-fi dystopia levels of ugly if we don’t work to prevent those outcomes.
      - wongarsu 7y ago
        We already limit astronauts and many other professions based on genetic properties: height, tollerance to high g-forces, eyesight etc. Even things used as health indicators like resting blood pressure are influenced to a significant degree by genetics. I think we will survive adding a few more genetic properties to the job requirements, especially since jobs on planets will vastly outnumber jobs in outer space for the forseeable future.
      - wil421 7y ago
        Sounds like Gattaca. It a very slippery slope when you start to genetically engineering people.
mxwsn 8y ago
I'm impressed by the paper's 16 co-first authors and 13 co-last corresponding authors. While something like this might be more routine in a field like physics, it's a good look for biology and I hope the trend of sharing credit continues.
- mruts 7y ago
  I got coauthored for formatting my coworker’s paper with LateX in the field of computational biology. So don’t get too excited.
  - dcdanko 7y ago
    The standards for authorship in this study were pretty strict. Something like ~2 supplementary figures just for a co-authorship. Source: I'm in one of the labs on this paper (but not one of the authors)
RJIb8RBYxzAMX9u 7y ago
> [S]patial orientation and motor praxis accuracy increased...cognitive speed decreased. It's too bad they didn't measure if TW's become empathic vs. HR. I guess we'll never know how well he's at piloting giant robots.
mirimir 7y ago
It's interesting that there's no mention of sperm count. I mean, given that the US government funded studies where state prisoners in Oregon and Washington sat on X-ray machines. After tracking the time course of sperm-count recovery, prisoners' testicles were typically removed. This was back in the 60s, in support of the space program. https://bioethicsarchive.georgetown.edu/achre/commeet/meet8/brief8/tab_e/br8e2.html https://bioethicsarchive.georgetown.edu/achre/commeet/meet8/...

105 points by miobrien 8y ago

Interesting that telomere length increased by 14% during flight! And, it can’t be related to a healthy lifestyle since they got shorter within 48hrs back on earth? Notably, telomere length shortened rapidly upon TW’s return to Earth, within ~48 hours [FD340 ambient return to R+0 (R+ days post return); fig. S6B] and stabilized to near preflight averages within months.

stcredzero 7y ago
I am not a doctor, but my understanding is that increasing telomere length could contribute to the severity of malignant tumors.
- z3t4 7y ago
  or increase life length!? Space hypersleep might become a thing after all.
  - stcredzero 7y ago
    It's a double edged sword. Increased telomere length will not only make it easier for your normal cells to divide more, it makes it easier for cancer cells to divide more. It's actually an anti-cancer adaptation for some mammals to turn off their telomere repair.

kissickas 8y ago

> Most notably, cognitive speed decreased for all tests except for the DSST, and accuracy decreased for all domains except for spatial orientation postflight. TW’s cognitive efficiency (a combination of speed and accuracy across cognitive domains) was similar pre- and inflight relative to HR but was significantly lower postflight (P = 0.0016, Student’s t test). This postflight decline in cognitive performance persisted up to 6 months postflight in both speed and accuracy domains (Fig. 10C). This is terrifying to me. I hadn't heard of spaceflight (or the return from it) affecting cognitive function before, but they don't seem to be making it a major issue here - even after it persisted six months later. Does anyone have older sources showing the same thing? I would especially be interested in studies showing the effect over multiple flights and returns to Earth.

scottie_m 7y ago
It’s not a study, but it’s been hypothesized that radiation and cosmic rays could cause lasting damage of just this sort through particle showers within the brain. Truthfully though there is very little in the way of studies for the simple fact that it’s hard to set one up for astronauts. Given how radically different the environment in space is compared to Earth though, I’m not finding this surprising. I wouldn’t be surprised if it’s just the tip of a very dangerous iceberg too, and it turns out that it takes a lot of time and sacrifice to get us to live and thrive somewhere other than Earth’s surface.
- fumar 7y ago
  We have a small sample size of humans who have been exposed to space. I wonder what human mutations will be more preferable for space travel. Physical fitness is part of the equation but so is genetic-space compatibility.
  - scottie_m 7y ago
    Agreed. Genentic engineering will probably be helpful, but first we do as you say, have to know what to engineer for. Then of course we’ll have a kind of speciation event and we’ll risk having a kind of genetic apartheid based on people who work in space vs. planetside. It could get sci-fi dystopia levels of ugly if we don’t work to prevent those outcomes.
    - wongarsu 7y ago
      We already limit astronauts and many other professions based on genetic properties: height, tollerance to high g-forces, eyesight etc. Even things used as health indicators like resting blood pressure are influenced to a significant degree by genetics. I think we will survive adding a few more genetic properties to the job requirements, especially since jobs on planets will vastly outnumber jobs in outer space for the forseeable future.
    - wil421 7y ago
      Sounds like Gattaca. It a very slippery slope when you start to genetically engineering people.

mxwsn 8y ago

I'm impressed by the paper's 16 co-first authors and 13 co-last corresponding authors. While something like this might be more routine in a field like physics, it's a good look for biology and I hope the trend of sharing credit continues.

mruts 7y ago
I got coauthored for formatting my coworker’s paper with LateX in the field of computational biology. So don’t get too excited.
- dcdanko 7y ago
  The standards for authorship in this study were pretty strict. Something like ~2 supplementary figures just for a co-authorship. Source: I'm in one of the labs on this paper (but not one of the authors)

RJIb8RBYxzAMX9u 7y ago

> [S]patial orientation and motor praxis accuracy increased...cognitive speed decreased. It's too bad they didn't measure if TW's become empathic vs. HR. I guess we'll never know how well he's at piloting giant robots.

mirimir 7y ago

It's interesting that there's no mention of sperm count. I mean, given that the US government funded studies where state prisoners in Oregon and Washington sat on X-ray machines. After tracking the time course of sperm-count recovery, prisoners' testicles were typically removed. This was back in the 60s, in support of the space program. https://bioethicsarchive.georgetown.edu/achre/commeet/meet8/brief8/tab_e/br8e2.html https://bioethicsarchive.georgetown.edu/achre/commeet/meet8/...