Some of that larger scale complexity may be due to irreducable emergent relationships that reductionism alone can't explain without essentially simulating those

Some of that larger scale complexity may be due to irreducable emergent relationships that reductionism alone can't explain without essentially simulating those reductionist relationships to the scale you need from the ground up (which defeats some of the goals of reductionism). You may need perfect information in order to fully simulate such systems (a snapshot of all initial conditions and perfect knowledge of physical laws). This may be the case for many scales of relationships we're interested in. Current reductionist theories can't tell me if I'm going to have coffee tomorrow morning. I don't expect them to either, yet they still have very useful purposes. They may never be able to tell me if I have coffee tomorrow and I'm fine with that (maybe due to error propagation inherent in quantum mechanical principles or the need for say emergent models).