4 ms·

Access to medical research articles through Sci-Hub has saved the lives of at least two people whom I know. Well done, Ms. Elbakyan.

radus 8y ago
Could you elaborate?
smadsen 8y ago
I would love to hear specifics if you can share them. Personally, I've used articles obtained through Sci-Hub to guide my approach to managing my own rare health condition. I wouldn't say it saved my life, but I've found the information very useful in figuring out the relative merits of new treatment options. In particular, there is one specialty journal that's only available by institutional subscription at a cost of more than $2,000 per year. The publisher was particularly unhelpful in trying to find a way to enable access for patients. So despite trying to do the right thing, I just go to Sci-Hub to get this info.
pessimizer 8y ago
She saved me from an unnecessary surgery. It's an amazing resource and is the commons we should have always had. None of these journals are funding any of this research.
iamcreasy 8y ago
Please elaborate. I'd love to hear the full story.
ridgeguy 8y ago
re inquiries as to specifics: both cases involved treatment-resistant depression with acute suicidal crises. One is a family member, the other a friend-of-friend. Many of you are aware that Ketamine has been used off-label for rapid treatment of depression and that one of its enantiomers, S-ketamine, has been (I think) approved for clinical treatment of depression. In these two cases, it was not possible to quickly access either a ketamine formulation or a physician who was familiar with its use. Google search showed that dextromorphan (yes, the OTC cough suppressant) has similarities to ketamine in its receptor targeting and is being tried in cases of treatment resistant depression. Combined with quinidine (as Neudexta, I think), it is used to treat a condition called pseudo bulbar affect. All the papers on use of dextromethorphan for depression were paywalled. Thanks to Sci-Hub, I was able to access and annotate 23 papers that together gave enough information (side effects, med interactions, etc.) for the two treating physicians to try dextro with their patients. Results are N=2, so obviously anecdotal, but both patients experienced recession of suicidal impulses within 48 hours and both continue to show decreasing depressive symptoms. I believe that neither of them would be with us now but for Ms. Elbakyan's work. I'm deeply grateful for what she's done.

radus 8y ago

Could you elaborate?

smadsen 8y ago

I would love to hear specifics if you can share them. Personally, I've used articles obtained through Sci-Hub to guide my approach to managing my own rare health condition. I wouldn't say it saved my life, but I've found the information very useful in figuring out the relative merits of new treatment options. In particular, there is one specialty journal that's only available by institutional subscription at a cost of more than $2,000 per year. The publisher was particularly unhelpful in trying to find a way to enable access for patients. So despite trying to do the right thing, I just go to Sci-Hub to get this info.

pessimizer 8y ago

She saved me from an unnecessary surgery. It's an amazing resource and is the commons we should have always had. None of these journals are funding any of this research.

iamcreasy 8y ago

Please elaborate. I'd love to hear the full story.

ridgeguy 8y ago

re inquiries as to specifics: both cases involved treatment-resistant depression with acute suicidal crises. One is a family member, the other a friend-of-friend. Many of you are aware that Ketamine has been used off-label for rapid treatment of depression and that one of its enantiomers, S-ketamine, has been (I think) approved for clinical treatment of depression. In these two cases, it was not possible to quickly access either a ketamine formulation or a physician who was familiar with its use. Google search showed that dextromorphan (yes, the OTC cough suppressant) has similarities to ketamine in its receptor targeting and is being tried in cases of treatment resistant depression. Combined with quinidine (as Neudexta, I think), it is used to treat a condition called pseudo bulbar affect. All the papers on use of dextromethorphan for depression were paywalled. Thanks to Sci-Hub, I was able to access and annotate 23 papers that together gave enough information (side effects, med interactions, etc.) for the two treating physicians to try dextro with their patients. Results are N=2, so obviously anecdotal, but both patients experienced recession of suicidal impulses within 48 hours and both continue to show decreasing depressive symptoms. I believe that neither of them would be with us now but for Ms. Elbakyan's work. I'm deeply grateful for what she's done.