3 ms·

I agree, but regarding this particular drug, > it has already been shown to be safe. > In 2007 this compound was tested in humans as a potential treatment for

I agree, but regarding this particular drug, > it has already been shown to be safe. > In 2007 this compound was tested in humans as a potential treatment for obesity and type 2 diabetes because it improves cell sensitivity to insulin. The studies, regulated by the U.S. Food and Drug Administration, demonstrated that MSI-1436 was well tolerated at high doses and did not harm patients.

radus 8y ago
That's a great sign, and a really nice target to choose to develop. This doesn't mean that it will be safe in another patient population (though it'll probably be okay), nor do these animal studies guarantee efficacy in humans. Humans have very different regenerative potentials compared to mice or zebrafish, or a more extreme example: axolotl. Additionally, drugs that target regeneration must walk a fine line between regenerating damaged tissue and overstimulating growth pathways (cancer).