4 ms·

Ashwagandha works great. It is well studied too (check ksm-66). Prolonged use is safe and has no side effects. Depression is a result of hormonal imbalance whic

Ashwagandha works great. It is well studied too (check ksm-66). Prolonged use is safe and has no side effects. Depression is a result of hormonal imbalance which it corrects effectively along with aiding with deep sleep when taken at nights. Exercise raises few hormones like endorphin, serotonin and reduces cortisol (depending on the kind of exercise, like long walks), but I am not convinced if someone says it balances them.

tomhoward 8y ago
> Ashwagandha works great I've used that at times, and it's been somewhat beneficial some of the time. But there's no silver bullet and no one-size-fits-all approach. The causes are complex and different from one person to another, so a complete recovery will require multiple forms of treatment and a tailored approach.
kekebo 8y ago
Depression correlates with hormonal changes, but saying it's a result of it is reductionistic and inaccurate. Depression also highly correlates with changes in inflammatory markers called cytokines[1], but reducing it to a single biological factor never yields an accurate pathogenesis of the disease. Robert Sapolskys Stanford Lecture gives a good overview of the interaction an relationship of the main risk factors causing depression[2]. [1] https://scholar.google.com/scholar?q=depression+cytokines+meta https://scholar.google.com/scholar?q=depression+cytokines+me... [2] https://www.youtube.com/watch?v=NOAgplgTxfc https://www.youtube.com/watch?v=NOAgplgTxfc [Robert Sapolsky On Depression]
- rygxqpbsngav 8y ago
  Great. May be I am wrong. But just found that Ashwagandha regulates Cytokines too. https://www.spandidos-publications.com/ijmm/42/1/425 https://www.spandidos-publications.com/ijmm/42/1/425 I think its use for stress & anxiety reduction is studied too, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/
  - kekebo 8y ago
    It's not so much being wrong than just naming one piece of a more complex puzzle. A wide range of things affect cytokines, nutrition and exercise are central, but also cognitive stress and sleep, and lifestyle factors like smoking, alcohol, certain drugs like amphetamines, to just name a few. In general, expecting that the intake of some chemical will fix the multitude of factors contributing to this complex disease seems short sighted and may create false hopes in people suffering from it, so far no easy chemical fix has been found or it would instantly replace SSRIs in their lacking efficacy. For me personally the only things that helped over long were radical mental discipline (daily mindfulness, cognitive behavior therapy), daily exercise, nutritional changes and a willingness to be comfortable being uncomfortable to make those changes.
    - rygxqpbsngav 8y ago
      Agree. I am a strong believer of treating things without medicines at all. Although I do take herbal supplements proven through centuries to be safe. One thing I can be sure is, there is no negative effect using ashwagandha. > A wide range of things affect cytokines, nutrition and exercise are central, but also cognitive stress and sleep If that is true, you get best sleep when using Ashwagandha and its effect on stress, like I said previously is well studied. https://examine.com/supplements/ashwagandha/ https://examine.com/supplements/ashwagandha/ it is there for centuries and affects in a multitude of ways for a body to bring it into balance in every front. In ayurveda, if a practitioner or doctor was unable to diagnose a disease properly, they simply give them Ashwagandha, as it will work or fail to but never works adversely. I still strongly recommend trying it with any other interventions you mentioned like exercise, etc. I never discouraged any other interventions. It helped me personally, so I am inclined to suggest it to others who are hopeless at the moment. Like I said, zero harm. I never suggested it as a one shot solution. People with depression need more caring than any other.
    - rygxqpbsngav 8y ago
      I have to disagree with the false hopes part. Just went to find some reviews(in 100s) on aswagandha products who gave 5 star reviews who claim it helped them with their depression better than prescribed ones. I think we are getting lost in the loop again - "I won't take it until it is well studied" while rest of the people already befitting from it without any side effects reported. Problem is no one wants to do it for other medicines like "Metformin" which is proven to result in a person getting promoted to insulin injections later. Strangely no one till date knows how it works! Diabetes is similar too, it happens because of a multitude of factors, yet it all reduced to one single medicine "Metformin". Did you ever question that? Why?
raducu 8y ago
Doesn't ashwagandha interfere with thyroid hormones? I've used it occasionally before bed and it did seem to reduce stress, but I'm not sure how much it was placebo.
- rygxqpbsngav 8y ago
  Yes. It does. It is an adaptogenic. It lowers if you have high thyroid, and raises if you have low.
  - tomhoward 8y ago
    The problem is it doesn’t address the underlying reason why your hormones are high or low. It might be for some important reason to keep your body in homeostasis while dealing with a different problem. Other literature I’ve read suggests that, for this very reason, prolonged use of adaptogens (including maca, rhodiola, ginseng) is inadvisable. In my own case, I suspect it may have led to problems (e.g., caused HPA axis to slow down further) after a while, having shown benefits in the beginning. Long story short: the body always fights back.
    - rygxqpbsngav 8y ago
      This is spot on. if there is something in the body already messed up, fixing the root cause is the only way. The body always fight back.

tomhoward 8y ago

> Ashwagandha works great I've used that at times, and it's been somewhat beneficial some of the time. But there's no silver bullet and no one-size-fits-all approach. The causes are complex and different from one person to another, so a complete recovery will require multiple forms of treatment and a tailored approach.

kekebo 8y ago

Depression correlates with hormonal changes, but saying it's a result of it is reductionistic and inaccurate. Depression also highly correlates with changes in inflammatory markers called cytokines[1], but reducing it to a single biological factor never yields an accurate pathogenesis of the disease. Robert Sapolskys Stanford Lecture gives a good overview of the interaction an relationship of the main risk factors causing depression[2]. [1] https://scholar.google.com/scholar?q=depression+cytokines+meta https://scholar.google.com/scholar?q=depression+cytokines+me... [2] https://www.youtube.com/watch?v=NOAgplgTxfc https://www.youtube.com/watch?v=NOAgplgTxfc [Robert Sapolsky On Depression]

rygxqpbsngav 8y ago
Great. May be I am wrong. But just found that Ashwagandha regulates Cytokines too. https://www.spandidos-publications.com/ijmm/42/1/425 https://www.spandidos-publications.com/ijmm/42/1/425 I think its use for stress & anxiety reduction is studied too, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/
- kekebo 8y ago
  It's not so much being wrong than just naming one piece of a more complex puzzle. A wide range of things affect cytokines, nutrition and exercise are central, but also cognitive stress and sleep, and lifestyle factors like smoking, alcohol, certain drugs like amphetamines, to just name a few. In general, expecting that the intake of some chemical will fix the multitude of factors contributing to this complex disease seems short sighted and may create false hopes in people suffering from it, so far no easy chemical fix has been found or it would instantly replace SSRIs in their lacking efficacy. For me personally the only things that helped over long were radical mental discipline (daily mindfulness, cognitive behavior therapy), daily exercise, nutritional changes and a willingness to be comfortable being uncomfortable to make those changes.
  - rygxqpbsngav 8y ago
    Agree. I am a strong believer of treating things without medicines at all. Although I do take herbal supplements proven through centuries to be safe. One thing I can be sure is, there is no negative effect using ashwagandha. > A wide range of things affect cytokines, nutrition and exercise are central, but also cognitive stress and sleep If that is true, you get best sleep when using Ashwagandha and its effect on stress, like I said previously is well studied. https://examine.com/supplements/ashwagandha/ https://examine.com/supplements/ashwagandha/ it is there for centuries and affects in a multitude of ways for a body to bring it into balance in every front. In ayurveda, if a practitioner or doctor was unable to diagnose a disease properly, they simply give them Ashwagandha, as it will work or fail to but never works adversely. I still strongly recommend trying it with any other interventions you mentioned like exercise, etc. I never discouraged any other interventions. It helped me personally, so I am inclined to suggest it to others who are hopeless at the moment. Like I said, zero harm. I never suggested it as a one shot solution. People with depression need more caring than any other.
  - rygxqpbsngav 8y ago
    I have to disagree with the false hopes part. Just went to find some reviews(in 100s) on aswagandha products who gave 5 star reviews who claim it helped them with their depression better than prescribed ones. I think we are getting lost in the loop again - "I won't take it until it is well studied" while rest of the people already befitting from it without any side effects reported. Problem is no one wants to do it for other medicines like "Metformin" which is proven to result in a person getting promoted to insulin injections later. Strangely no one till date knows how it works! Diabetes is similar too, it happens because of a multitude of factors, yet it all reduced to one single medicine "Metformin". Did you ever question that? Why?

raducu 8y ago

Doesn't ashwagandha interfere with thyroid hormones? I've used it occasionally before bed and it did seem to reduce stress, but I'm not sure how much it was placebo.

rygxqpbsngav 8y ago
Yes. It does. It is an adaptogenic. It lowers if you have high thyroid, and raises if you have low.
- tomhoward 8y ago
  The problem is it doesn’t address the underlying reason why your hormones are high or low. It might be for some important reason to keep your body in homeostasis while dealing with a different problem. Other literature I’ve read suggests that, for this very reason, prolonged use of adaptogens (including maca, rhodiola, ginseng) is inadvisable. In my own case, I suspect it may have led to problems (e.g., caused HPA axis to slow down further) after a while, having shown benefits in the beginning. Long story short: the body always fights back.
  - rygxqpbsngav 8y ago
    This is spot on. if there is something in the body already messed up, fixing the root cause is the only way. The body always fight back.