Interestingly, the drug-resistant cancer cells are also less "efficient" than non-drug-resistant cancer cells. This can be exploited by the "drug holiday effect

Interestingly, the drug-resistant cancer cells are also less "efficient" than non-drug-resistant cancer cells. This can be exploited by the "drug holiday effect" - give patient drug number 1 - resistant population takes over, change drug - non-resistant population wins again and drug number 1 works again https://www.nki.nl/topmenu/about-the-nki/news/drug-holiday-effect-in-patients-with-melanoma-resolved/ https://www.nki.nl/topmenu/about-the-nki/news/drug-holiday-e...