Exactly. Seizures represent massively synchronized electrical activity, so it’s a bit surprising that they’re associated with chemical changes big enough to be

Exactly. Seizures represent massively synchronized electrical activity, so it’s a bit surprising that they’re associated with chemical changes big enough to be detected outside the body. We do know that this electrical activity is controlled via ion channels and other chemical mechanisms. So a neuroscientist could well have guessed that this might be the case. But we have all sorts of hypotheses about what “really happens” in the brain. It’s such a fantastically complex system, though, that they’re not too useful for extrapolation in the absence of data.