Representiveness is an issue, but I think the most important are the multiple comparisons problem and the base-rate fallacy. It's commonly the case that a P<0.0

Representiveness is an issue, but I think the most important are the multiple comparisons problem and the base-rate fallacy. It's commonly the case that a P<0.05 positive result has more than a 50% chance of being wrong. The replication studies I've seen mainly point to these factors being the issue. The fundamental thread is neglect of prior information.