Absolutely. I've (unfortunately) done some work on a vertical market app for homebuilders that is mostly written in Excel. If you're using the Office COM API, t

Absolutely. I've (unfortunately) done some work on a vertical market app for homebuilders that is mostly written in Excel. If you're using the Office COM API, there is some syntactical sugar that VB.NET handles for you that makes it far easier to write VB.NET over C#, as much as I'd prefer to use it. Theoretically I could abstract it out and have VB.NET wrappers, but considering the rest of the app is written inside of Excel using VBA, it just seemed to make more sense to leave it in VB.NET (read: lazy programmer).