6 ms·

I’ve concluded (for myself) that triggering autophagy is the easiest, free thing I can do every day to cull bad cells in my body that may lead to cancer/speed u

I’ve concluded (for myself) that triggering autophagy is the easiest, free thing I can do every day to cull bad cells in my body that may lead to cancer/speed up aging.

andreygrehov 8y ago
How do you trigger autophagy?
- majewsky 8y ago
  Fasting has been suggested (shown?) to induce autophagy after you've been doing it for several days. Disclaimer: I am not a doctor. Consult a doctor or nutritionist before changing your diet.
- sjcsjc 8y ago
  Fasting is one way. Look in Google scholar. One example below. https://www.tandfonline.com/doi/abs/10.4161/auto.6.6.12376 https://www.tandfonline.com/doi/abs/10.4161/auto.6.6.12376
est31 8y ago
Autophagy pathways are disrupted in senescent and cancer cells otherwise autophagy would already have happened. Some way to avoid or fix that disruption might be an approach to fight cancer but even then, there are many more things going wrong in the body with increasing age. E.g. telomere shortening which is obviously a greater threat the more autophagy there is in your body. Aging is one of the most complex diseases that exist, maybe the most complex disease. Research on preventing and curing age is very welcome, but there isn't a single simple thing that can cure it. The cure for it will very likely be more complex than any other cure we've ever developed for any medical condition to this day.
- randomacct3847 8y ago
  I’m not suggesting autophagy cures aging, but there’s at least plenty of studies on genetically similar species that shows fasting can extend average lifespan.
  - gerdesj 8y ago
    So does decent, affordable (or "free"), healthcare. On balance I'll take NHS over autophagy.
    - barry-cotter 8y ago
      Randomised controlled trials disagree. Healthcare spending has amazingly small effects on outcomes. https://en.wikipedia.org/wiki/RAND_Health_Insurance_Experiment https://en.wikipedia.org/wiki/RAND_Health_Insurance_Experime... An early paper with interim results from the RAND HIE concluded that health insurance without coinsurance "leads to more people using services and to more services per user," referring to both outpatient and inpatient services.[5] Subsequent RAND HIE publications "rule[d] out all but a minimal influence, favorable or adverse, of free care for the average participant"[6] but determined that a "low income initially sick group assigned to the HMO... [had a] greater risk of dying" than those assigned to fee-for-service (FFS) care.[7] The experiment also demonstrated that cost sharing reduced "appropriate or needed" medical care as well as "inappropriate or unnecessary" medical care. https://en.wikipedia.org/wiki/Oregon_Medicaid_health_experiment https://en.wikipedia.org/wiki/Oregon_Medicaid_health_experim... Approximately two years after the lottery, researchers found that Medicaid had no statistically significant impact on physical health measures, but "it did increase use of health care services, raise rates of diabetes detection and management, lower rates of depression, and reduce financial strain."[4][5]
- SubiculumCode 8y ago
  And frankly, that pisses me off. Getting older sucks...and I am just in my early 40's.
seizethecheese 8y ago
I run in the morning before eating breakfast with the theory that it triggers autophafy. I’d be curious if I’m wrong.
- gerdesj 8y ago
  You are a much fitter person for your morning run than without it - good skills. Ditch the fags and booze and you might live to tomorrow. You are still curious.
- 0x8BADF00D 8y ago
  It triggers catabolism certainly. So as a result, apoptosis inducing metabolic pathways will be triggered.
JPLeRouzic 8y ago
I agree, but there are cells that we do not want to die, because if they die they will not be replaced (they do not divide and there is no stem cell regenerating their pool): * Neurons * Retina cells and probably many others. Another thing is cells that are dying are rising inflammation to the point it could trigger auto-immune diseases.

I’ve concluded (for myself) that triggering autophagy is the easiest, free thing I can do every day to cull bad cells in my body that may lead to cancer/speed up aging.

andreygrehov 8y ago

How do you trigger autophagy?

majewsky 8y ago
Fasting has been suggested (shown?) to induce autophagy after you've been doing it for several days. Disclaimer: I am not a doctor. Consult a doctor or nutritionist before changing your diet.
sjcsjc 8y ago
Fasting is one way. Look in Google scholar. One example below. https://www.tandfonline.com/doi/abs/10.4161/auto.6.6.12376 https://www.tandfonline.com/doi/abs/10.4161/auto.6.6.12376

est31 8y ago

Autophagy pathways are disrupted in senescent and cancer cells otherwise autophagy would already have happened. Some way to avoid or fix that disruption might be an approach to fight cancer but even then, there are many more things going wrong in the body with increasing age. E.g. telomere shortening which is obviously a greater threat the more autophagy there is in your body. Aging is one of the most complex diseases that exist, maybe the most complex disease. Research on preventing and curing age is very welcome, but there isn't a single simple thing that can cure it. The cure for it will very likely be more complex than any other cure we've ever developed for any medical condition to this day.

randomacct3847 8y ago
I’m not suggesting autophagy cures aging, but there’s at least plenty of studies on genetically similar species that shows fasting can extend average lifespan.
- gerdesj 8y ago
  So does decent, affordable (or "free"), healthcare. On balance I'll take NHS over autophagy.
  - barry-cotter 8y ago
    Randomised controlled trials disagree. Healthcare spending has amazingly small effects on outcomes. https://en.wikipedia.org/wiki/RAND_Health_Insurance_Experiment https://en.wikipedia.org/wiki/RAND_Health_Insurance_Experime... An early paper with interim results from the RAND HIE concluded that health insurance without coinsurance "leads to more people using services and to more services per user," referring to both outpatient and inpatient services.[5] Subsequent RAND HIE publications "rule[d] out all but a minimal influence, favorable or adverse, of free care for the average participant"[6] but determined that a "low income initially sick group assigned to the HMO... [had a] greater risk of dying" than those assigned to fee-for-service (FFS) care.[7] The experiment also demonstrated that cost sharing reduced "appropriate or needed" medical care as well as "inappropriate or unnecessary" medical care. https://en.wikipedia.org/wiki/Oregon_Medicaid_health_experiment https://en.wikipedia.org/wiki/Oregon_Medicaid_health_experim... Approximately two years after the lottery, researchers found that Medicaid had no statistically significant impact on physical health measures, but "it did increase use of health care services, raise rates of diabetes detection and management, lower rates of depression, and reduce financial strain."[4][5]
SubiculumCode 8y ago
And frankly, that pisses me off. Getting older sucks...and I am just in my early 40's.

seizethecheese 8y ago

I run in the morning before eating breakfast with the theory that it triggers autophafy. I’d be curious if I’m wrong.

gerdesj 8y ago
You are a much fitter person for your morning run than without it - good skills. Ditch the fags and booze and you might live to tomorrow. You are still curious.
0x8BADF00D 8y ago
It triggers catabolism certainly. So as a result, apoptosis inducing metabolic pathways will be triggered.

JPLeRouzic 8y ago

I agree, but there are cells that we do not want to die, because if they die they will not be replaced (they do not divide and there is no stem cell regenerating their pool): * Neurons * Retina cells and probably many others. Another thing is cells that are dying are rising inflammation to the point it could trigger auto-immune diseases.