3 ms·
My general rule of thumb is if I'm having a debate about statistical significance, I'm debating the wrong thing, should stop talking, and get more data. Prefera
by killjoywashere 8y ago
My general rule of thumb is if I'm having a debate about statistical significance, I'm debating the wrong thing, should stop talking, and get more data. Preferably so much more data that the question answers itself without having to test for significance.
- atlasair 8y agoThis doesn't work, if you need expose patients to a novel drug to gather data.
- killjoywashere 8y agoThe era of medicine where we administer a 100 mg pill of a small molecule to 3000 patients, calculate a P value and release it for sale is dead. There's a huge industry, so it's not aware of its death yet, but the research world has moved on. I think the paradigm will be based around deep understanding of the genomics, proteomics, histology, spatial distribution of the problem in the body, and licensing for sale platforms that produce custom proteins, T cells, small molecules, <intervention of choice>, designed on the fly. It's 30 years out, but if you're betting the bank on a small molecule in a phase 3 trial, that model is only going to hold up for so long.