> The mechanism of action of analgesic drugs is very simple and well-understood. https://academic.oup.com/bjaed/article/14/4/153/293533 https://academic.oup.co

> The mechanism of action of analgesic drugs is very simple and well-understood. https://academic.oup.com/bjaed/article/14/4/153/293533 https://academic.oup.com/bjaed/article/14/4/153/293533 (2013) the exact mechanism of action of paracetamol [ie acetamophen] remains to be determined. There is evidence for a number of central mechanisms, including effects on prostaglandin production, and on serotonergic, opioid, nitric oxide (NO), and cannabinoid pathways, and it is likely that a combination of interrelated pathways are in fact involved. That's the most widely-used analgesic in the world, and its mechanism is evidently neither simple nor well-understood.