> This questionnaire included a series of questions about whether respondents had a specific psychiatric condition, including depression or anxiety (categorical

> This questionnaire included a series of questions about whether respondents had a specific psychiatric condition, including depression or anxiety (categorical response options: yes, no, unsure), and whether their conditions had changed (categorical response options: better, stayed the same, worsened) after 5-MeO-DMT use. This is a self-reported study. Asking whether a substance or drug improved someone condition will often result in positive answers, whether or not it was therapeutically useful. In the sample, more than 90% of individuals had already used 5-MeO-DMT, 41% had depression, 48% with anxiety. 79% reported that “their anxiety was better following 5-MeO-DMT use”. This is indeed not a balanced sample, and self-reports provide very weak results compared to a proper double-blind study. While doing a double-blind study on such substances might be challenging, there are definitely tools and environments that can help correctly measure the true effect of a substance on depression on anxiety. I don't see how this study proves anything.