Presuming all backgrounds of people who have had different evolutionary paths are the same or would react the same biologically to different chemicals doesn't m

Presuming all backgrounds of people who have had different evolutionary paths are the same or would react the same biologically to different chemicals doesn't make sense to me. For example, many Asians from my current understanding - and correct me if I'm wrong, can't process Alcohol the same way the rest of us can - which leads a higher percentage of them getting a red face. I too would get a bit of a "high" - whether it's the same experience that we both have or not, for me it also would cause me ADD/focus problems for many hours afterward and give me a headache. You're right that some people could become conditioned or accustomed to it if they eat it regularly, however I wonder then what the long-term impact is - and how easy it would be to measure more subtle impact.