Given that wookie's author uses vim it is clearly possible. Another prominent lisper that uses vim is Steve Losh, they've even written their own swank equivalen

Given that wookie's author uses vim it is clearly possible. Another prominent lisper that uses vim is Steve Losh, they've even written their own swank equivalent based on nrepl, cl-nrepl https://github.com/sjl/cl-nrepl https://github.com/sjl/cl-nrepl