[1] is fascinating, and gives a much better explanation of my comment above that "it's not as simple as the law of thermodynamics". The endocrinology and psych

[1] is fascinating, and gives a much better explanation of my comment above that "it's not as simple as the law of thermodynamics". The endocrinology and psychology of "why do we feel hungry?" and "why do we overeat?" are incredibly important to weight loss. That's not to say that you can't lose weight with caloric restriction - of course you can. But noone in the CICO* crowd can explain why most people struggle with it. It's easy to chalk it up to "weak-minded fatties". The more interesting question is - could we bolster the weak-minded through nutritional adjustment, supplements or fecal transplants? * Calories-in, calories-out