I've read anecdotally this applies to drug tolerance too. If an addict uses a drug in an unfamiliar setting their body won't have steeled itself to expect it, a

I've read anecdotally this applies to drug tolerance too. If an addict uses a drug in an unfamiliar setting their body won't have steeled itself to expect it, and they can overdose more easily. It was definitely a weird idea when I first heard it.