> I have repeatedly said in this thread this doesn't apply to diabetics, who do have an insulin pathology. Diabetics do need to worry about insulin, non-diabeti

> I have repeatedly said in this thread this doesn't apply to diabetics, who do have an insulin pathology. Diabetics do need to worry about insulin, non-diabetics do not. Point taken :-) > There is no science that disambiguates between large spikes followed by zero food in take (IF), and small spikes continually at the same calorie levels. Please feel free to send any study you think does. and > No, this is only true if you are eating all the time and also eating too many calories. . Again, please send a link to a study you think says otherwise. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079942/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079942/ > Why are you not a fan of the only kind of study that could possibly prove your point? Because you're on a circadian clock with lots of hormonal regulations that have huge influence on you. Most people won't feel as hungry on a fat-heavy diet as on a low-calorie (mostly low-fat) diet. Long-term adherence to low-calorie diets is just not working out for most people. Yes, calorie-restriction works in basically every living thing to prolong life. No, people will not do it. > And why hasn't this study ever been successfully completed? Why have studies that attempted to do this been unable to show any difference in outcomes? There is evidence. Please don't tell me there is conclusive evidence on anything related to nutrition. The second statement is not true, differences have been shown. > I don't really know what you're implying here, but I suspect you are still getting hamstrung by the prandial window. Yes, insulin can block your ability to access fat in the short term, no it will not in the long term, and it does not do so entirely either. If you are eating the same number of calories and thus constantly releasing insulin you are blocking some, but not all, lipolysis. Lipolysis is not a binary, nor is insulin release. You can have both of them happening at the same time, even though insulin is blocking some of the lipolysis. Yes, it's not binary, but the easy way to increase lipolysis is to decrease insulin.