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The really crazy effect of insulin is how it interacts with aging. The link between insulin and aging is super well understood. https://www.ncbi.nlm.nih.gov/pm

The really crazy effect of insulin is how it interacts with aging. The link between insulin and aging is super well understood. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906894/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906894/ If you're interested in the Ted talk version: https://www.ted.com/talks/cynthia_kenyon_experiments_that_hint_of_longer_lives?language=en https://www.ted.com/talks/cynthia_kenyon_experiments_that_hi... She now works at Calico, Google's longevity play. If there was one area I was going to do something besides agriculture this is what I would work on.

wdewind 8y ago
> The link between insulin and aging is super well understood. This is really overstated. The paper is a paper on round worms, which is really one step above basic cellular science (which is important but only a building block of the whole picture). We do not have large scale, epidemiological studies about sugar, and the ones that we do don't point to sugar behaving differently than other calories with regards to health outcomes. The problem is blood sugar not dietary sugar, and it turns out high blood sugar can come from many places that are not dietary sugar, and a calorically controlled diet that is high in sugar does not result in high average blood sugar levels.
- estsauver 8y ago
  * Agreed on blood sugar vs. dietary sugar. * This paper launched a whole series of mouse studies.
  - wdewind 8y ago
    If you have any that disambiguate between average and peak blood glucose levels I would be really interested in reading them! To my knowledge no one is really studying this because it is hard and if you are successful proving that knowledge we came up with in the 50s still holds isn't very attractive for most research institutes :(