4 ms·

There is evidence that nicotine alone is a complete carcinogen. It is pretty damaging on its own.

mdekkers 8y ago
There is evidence that nicotine alone is a complete carcinogen That's the first time I heard that. Do you have any links to this evidence?
01100011 8y ago
Love to see a reference for that. Scientific American had an article a while back saying exactly the opposite. https://www.scientificamerican.com/article/is-nicotine-all-bad/ https://www.scientificamerican.com/article/is-nicotine-all-b... FWIW, my friend's psychiatrist recommends nicotine gum.
- shereadsthenews 8y ago
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407298/?report=reader#!po=1.02041 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407298/?report...
  - wahern 8y ago
    > Experimental group of mice received subcutaneous injections of the LD50 dose of (−)nicotine hydrogen tartrate of 3 mg/kg/day, 5 days per week for 24 months, and control group received the vehicle phosphate-buffered saline. > ... > The purpose of this pilot study was to evaluate the pathobiologic effects of long-term, high dose nicotine treatment of A/J mice susceptible to tobacco product-induced lung carcinogenesis. These were mice genetically engineered for increased cancer susceptibility and also given insane dosages. This study is designed to answer whether nicotine is not carcinogenic. That is, if the result was negative then it would suggest any future study would be wasted effort. A positive result doesn't say anything about the safety of nicotine, per se; just that there remains the possibility it may be carcinogenic. That's very different as many absolutely benign substances could also produce this result.
- sosilkj 8y ago
  https://tobacco.ucsf.edu/cellular-evidence-how-nicotine-and-e-cigarettes-increase-cancer-risk-humans-and-mice https://tobacco.ucsf.edu/cellular-evidence-how-nicotine-and-...
- elp 8y ago
  Ummm... I see the article was written by a Kate Kelland from Reuters? Was this same person? "Reuters’ reporter Kate Kelland, who has a history of cozy relations with a group partly funded by agrichemical company interests," ( https://www.huffingtonpost.com/entry/monsanto-spin-doctors-target-cancer-scientist-in-flawed_us_594449eae4b0940f84fe2e57 https://www.huffingtonpost.com/entry/monsanto-spin-doctors-t...)
who_is_firing 8y ago
We actually have no idea. It is entirely possible but its unclear at this point: "To our knowledge, there are no relevant study in humans on carcinogenic effects from pure nicotine including products, such as NRT and e-cigarettes." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553893/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553893/

There is evidence that nicotine alone is a complete carcinogen That's the first time I heard that. Do you have any links to this evidence?

01100011 8y ago

Love to see a reference for that. Scientific American had an article a while back saying exactly the opposite. https://www.scientificamerican.com/article/is-nicotine-all-bad/ https://www.scientificamerican.com/article/is-nicotine-all-b... FWIW, my friend's psychiatrist recommends nicotine gum.

shereadsthenews 8y ago
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407298/?report=reader#!po=1.02041 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407298/?report...
- wahern 8y ago
  > Experimental group of mice received subcutaneous injections of the LD50 dose of (−)nicotine hydrogen tartrate of 3 mg/kg/day, 5 days per week for 24 months, and control group received the vehicle phosphate-buffered saline. > ... > The purpose of this pilot study was to evaluate the pathobiologic effects of long-term, high dose nicotine treatment of A/J mice susceptible to tobacco product-induced lung carcinogenesis. These were mice genetically engineered for increased cancer susceptibility and also given insane dosages. This study is designed to answer whether nicotine is not carcinogenic. That is, if the result was negative then it would suggest any future study would be wasted effort. A positive result doesn't say anything about the safety of nicotine, per se; just that there remains the possibility it may be carcinogenic. That's very different as many absolutely benign substances could also produce this result.
sosilkj 8y ago
https://tobacco.ucsf.edu/cellular-evidence-how-nicotine-and-e-cigarettes-increase-cancer-risk-humans-and-mice https://tobacco.ucsf.edu/cellular-evidence-how-nicotine-and-...
elp 8y ago
Ummm... I see the article was written by a Kate Kelland from Reuters? Was this same person? "Reuters’ reporter Kate Kelland, who has a history of cozy relations with a group partly funded by agrichemical company interests," ( https://www.huffingtonpost.com/entry/monsanto-spin-doctors-target-cancer-scientist-in-flawed_us_594449eae4b0940f84fe2e57 https://www.huffingtonpost.com/entry/monsanto-spin-doctors-t...)

who_is_firing 8y ago

We actually have no idea. It is entirely possible but its unclear at this point: "To our knowledge, there are no relevant study in humans on carcinogenic effects from pure nicotine including products, such as NRT and e-cigarettes." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553893/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553893/