4 ms·
Already done. No dementia in family history, and the actual literature leaves much to be desired in terms of qualitative result. By the way I discourage the us
by themodelplumber 8y ago
Already done. No dementia in family history, and the actual literature leaves much to be desired in terms of qualitative result.
By the way I discourage the use of the term "linked" in light conversation as it has recently and unfortunately become a socio-culturally appropriated term indicating proof of causality. That a linkage exists often means far less than most people think, and this could immediately impact their health-related decision-making for the worse.
- GordonS 8y agoI didn't read the paper since it first came out (1-2 years ago?), but I seem to recall a clear causal link was found?
- themodelplumber 8y agoI would really encourage you to review the study again. For example, the authors themselves acknowledged a lot of legitimate reader concerns with the inclusion of this statement: "These observational studies have 4 important limitations. First, current anticholinergic use was ascertained at study entry and periodically during follow-up only by conducting a medication inventory. Second, these studies lacked information about the dose and duration of anticholinergic use. Third, these studies had short follow-up periods. This last point is important because the pathophysiological changes in the brains of patients with AD require several years to occur. Finally, these studies did not take into account that certain anticholinergics are used to manage insomnia and depression, prodromal conditions that can be seen in early but undiagnosed dementia, leading to protopathic bias." I had other concerns as well, and these items alone are a pretty big deal. Like I said above, the _quality_ of the establishment of a "link" is really leaving much to be desired here. This is barely even legitimate science, where any kind of causality is concerned. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2091745 https://jamanetwork.com/journals/jamainternalmedicine/fullar...
- GordonS 8y agoThanks for taking the time to provide a summary - I will indeed take another look (I have hydroxyzine at night, so it's very relevant for me)