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Neuroactive potential of human gut microbiota in quality of life and depression
- johnchristopher 8y agoSo.. for the non biochem crowd.. what should I eat to get the kind of bacteria that helps with depression ?
- throwaway-1283 8y agoOne consistent thing I've heard never to consume because it destroys gut bacteria is diet soda.
- dwringer 8y agoI have seen that idea popularized here on HN for sure - it seems almost every physical or mental health and diet related post gets a comment about "the gut microbiome" which either mentions or is replied to by a comment that claims diet soda "destroys" it. The frequency with which this is mentioned is definitely pretty high, but I've not come across any links to studies or further reading on the idea. EDIT: Here is what I believe to be a source of many such claims, a 2014 study suggesting that artificial sweeteners can alter gut flora in mice to lead them to being glucose intolerant: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615743/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615743/ I'd be interested if there's anything more recent or conclusive about this - plenty of sensationalistic articles seem to be out there either extrapolating from or challenging this study, but I'm not able to deduce anything further.
- thaumasiotes 8y agoMy low-information read of the current state of knowledge is: we've established at very high confidence that the gut microbiome really is very important. And that's it; we don't know anything more detailed than that.
- randomacct3847 8y agoThe state of nutrition science is so poor. But intuitively eating unprocessed foods that are not made with artificial or chemical anything (including artificial sweeteners) is probably a good start. Fasting is probably another good way to reset your gut.
- thaumasiotes 8y agoI don't think "resetting your gut" is a good way to think about it. Taking oral antibiotics will "reset your gut", in the sense of killing most of the existing biome and leaving space for new flora to grow into, but that can lead to problems as the biome that develops from a clean field isn't the same as the standard biome. To the best of my knowledge, you normally inherit your gut flora from your mother during birth and nursing, and then your gut hopefully stays stable over time. "Resetting" is more likely to give you a worse biome than a better one.
- randomacct3847 8y agoResetting by fasting is nothing like taking antibiotics https://www.sciencedirect.com/science/article/pii/S0960982218304433 https://www.sciencedirect.com/science/article/pii/S096098221...
- hamilyon2 8y agoDrosofila. Flies. Linked article is about flies.
- throwaway-1283 8y ago
- nickpsecurity 8y agoHere's some I saw about artificial sweeterners: https://www.nature.com/articles/nature14232 https://www.nature.com/articles/nature14232 http://www.israelscienceinfo.com/en/medecine/weizmann-israel-bacteries-intestinales-edulcorants-artificiels-intolerance-au-glucose/ http://www.israelscienceinfo.com/en/medecine/weizmann-israel... https://www.mdpi.com/1420-3049/23/2/367 https://www.mdpi.com/1420-3049/23/2/367
- _Schizotypy 8y agoI'd be interesting in reading some papers on this if anyone has them
- Mirioron 8y agoIs it because diet soda doesn't provide nutrition to gut bacteria, but still takes up the space actual nutrition could have been in, and thus the gut bacteria don't get access to as much nutrition? Edit: poor wording above. I meant to ask whether the artificial sweeteners could take the place of nutrition for the gut bacteria but not actually provide enough nutrition.
- ryanianian 8y ago(not a scientist but that doesn't seem plausible. water takes up equal space to diet soda and also provides no nutrition.)
- Mirioron 8y agoAh, I should've written a more generic "takes the place of" instead of space. I meant to ask something along the lines of whether the artificial sweeteners of diet sugar might be confused for nutrition by the gut bacteria. Basically, I was picturing a situation where the gut bacteria might try to "eat" the artificial sweeteners, but then don't end up getting enough energy from it and can't do the things they need to do.
- chongli 8y agoCouldn't you say the same thing about water?
- 8y ago
- theshrike79 8y agoCan confirm. The artificial sweeteners in Pepsi MAX make my farts smell goddamn awful. Coke Zero doesn't do that, but I still try to stay away from diet sodas.
- circlefavshape 8y agoKimchi - full of pro-biotics and good for your gut, apparently - is what makes my farts smell worst of all. Worst incident was a freshly-home-made batch, played bass in a show the after eating it at dinnertime and the smell actually made the drummer vomit :(
- CuriousSkeptic 8y agoThe SMILES trial ( http://foodandmoodcentre.com.au/media/smiles-trial/ http://foodandmoodcentre.com.au/media/smiles-trial/ ) had good resultat with their diet. But in general many different kinds of plant based foods to promote biodiversity. According to ( https://youtu.be/-LUuqxQSaFQ https://youtu.be/-LUuqxQSaFQ )
- thaumasiotes 8y agoPoop from somebody who isn't depressed. That sounds like I'm making it up, but unfortunately I'm not.
- fernly 8y agoYup. It's called a fecal microbial transplant (FMT) and it works for several problems, notably C-diff infection. (Unfortunately it isn't the first-line treatment for that nasty bug, it is usually preceded by weeks of antibiotics and only used when they fail. Source: personal experience.) https://en.wikipedia.org/wiki/Fecal_microbiota_transplant https://en.wikipedia.org/wiki/Fecal_microbiota_transplant https://en.wikipedia.org/wiki/Clostridioides_difficile_(bacteria)#Treatment https://en.wikipedia.org/wiki/Clostridioides_difficile_(bact...
- infimoinfinito 8y ago~~~I'm making it up~~~ You , my friend, didn´t made it up. I am sure. I am sure someone else made it up. You better eat the Evil Itself, Magnesium powder, then eat literally Shit. But maybe is a hard choice between Magnesium and shit (literally, poop) and Magnesium powder or even Almonds, that contains Magnesium, in my eXperience, like in a federal good wife´s court, your Honor
- bsanr 8y agoAlso: unfortunately, it's hard to get your hands on.
- fromthestart 8y agoI worry that there may be currently unknown compatibility issues between donors and recipients, and that a recipient could be worse off after the wrong donation.
- justanotherjoe 8y agoMy God... Alex Jones is going to have a field day... "they force our kid to eat poo poo!"
- cageface 8y agoI noticed a huge lift in my mood when I switched to a completely plant based diet but if that’s too radical for you I think you can get a lot of the benefits by just massively increasing the amount of fresh fruits and vegetables you eat and sticking to whole, unprocessed carbs. Adding some fermented foods like natto or kimchi should help too.
- theshrike79 8y agoI just stopped eating meat that had 4 legs at one point. (Beef, Pork, game meats) Digestion issues didn't go away completely, but everything is noticeably better now.
- ptah 8y agogoing plant based improved my health dramatically too. i used to think i was carnivorous. turns out i was just speeding up aging
- infimoinfinito 8y agoFrom God´s crowd, to the non biochem crowd... kinda should eat coconut water and drink 1 little shot of sea water directly from the ocean , no bottles, no cups, no using your hands to drink the water, must imerse your head in the ocean water and drink the shot of sea water directly in the Ocean
- Jedi72 8y agoNever seen a depressed person who had a full slice of cheesecake in front of them ;)
- therein 8y agoI bet at least one pharmaceutical giant is working on an extended-release cheesecake.
- jingalings 8y agoI get your jest, but as someone who struggles with depression and uses food as a coping mechanism, this is sadly not the case. My personal experiences also make me acutely aware of others in food courts who really aren’t enjoying the food they are consuming.
- scarecrowbob 8y agoWhat follows is purely anecdotal and just my experience, but protracted fasting had obvious changes on my general mental health. My experiences were a month of 3 day water fasts followed by a meal (whole foods like plants and steak), and since then (this was 2 years ago) I do a 3 day fast every 1-2 months or so. I also was able to stop craving sugars (sodas/ candy, etc) after that first long fast. I have nothing conclusive, but I suspect that the changes in my mental health and dietary cravings have to do with killing off chunks of my microbiome in the first long fast. Could just be either placebo or other life changes (I turned 40, my wife had left me a month before, and I gave up drinking for 6 months during and after the fast). So your milage may vary, but if your question is sincere, it might be easier to modify a biome by trimming it back rather than adding to it. I'd be super stoked to have contradictory / corroborating evidence, though.
- theshrike79 8y agoAnother voice for fasting from here too. I do 16:8 intermittent fasting and my energy levels are a lot better. Basically I just eat my last meal around 19:00 and skip breakfast. Lunch around 11:00. I may have a sugar free energy drink in the morning to pick me up (my poor stomach doesn't approve coffee any more, too much of it in my younger days... =) )
- cageface 8y agoI’ve been doing this too and I was skeptical but it does seem to be making a significant difference. My blood sugar levels are a lot more stable and I don’t get hungry and shaky anymore. I can easily skip another meal now too if needed and it’s no problem.
- johnfn 8y agoYour life left you a month before and you think that it wasn’t that but the fasting that affected your mental health?
- scarecrowbob 8y agoWell, who knows? The changes to my general modes of dealing with stuff were pretty dramatic. I don't think that my wife leaving made it easier to not eat sweets, but who knows? I was still pretty upset, I just wasn't suicidally depressed, which was a fair improvement. And as I have continued with the fasting through the months, I have felt better around those times when I'm fasting.
- dpflan 8y agoDoes anyone know about the role oral microbiome plays here?
- deleted 8y ago[deleted]
- harmful_stereo 8y agoKissing the wrong person could be a gateway to depression. I wonder how long it might be before one could sue for damage to their microbiome.
- cheeko1234 8y agoWow, didn't think of that. I wonder if that's a possibility. As a clueless person, I'd think the quantity and stomach acids would make it a negligible risk but worth studying.
- rlucas 8y agoBy that logic -- kissing a depressed person could just as well be a cure for their depression. Cheer up! (Pucker up?)
- afarrell 8y agoI feel like that would be easier to study because cheek-swabs are easier than colon-swabs.
- diyseguy 8y agoHow soon till the happiness pro-biotics are available for purchase?
- oregontechninja 8y agoPurely anecdotal but, I've been expirmenting drinking and making kefir and fermented veggies (mostly spinach). After a few days, my digestive system was the most regular it's ever been. I feel happier too but correlation vs causation and what not.
- comicjk 8y agoIf you're eating a lot of spinach, you could just be experiencing the well-known effects of dietary fiber.
- garraeth 8y agoTrue, and people are investigating new ideas about dietary fiber thinking that perhaps it's not just for "bulk" and helping keep things "regular": https://www.ncbi.nlm.nih.gov/pubmed/29902436 https://www.ncbi.nlm.nih.gov/pubmed/29902436 "In this review, we will focus on dietary fibers, which interact directly with gut microbes and lead to the production of key metabolites such as short-chain fatty acids, and discuss how dietary fiber impacts gut microbial ecology, host physiology, and health."
- cimmanom 8y agoI though it was already known that soluble fiber contributes to microbiome health (and not much to motility) and insoluble fiber is mostly helpful for bulk and motility. Does this study address the role of insoluble fiber in microbiome health?
- clydethefrog 8y agoInteresting, I thought spinach was a hard vegetable to ferment because it gets soft and sloppy quickly. Could you share a recipe?
- cageface 8y agoSpinach is great but don’t overdo it. The high oxalate content can cause problems for some people. Good to get a variety of different greens, of course including spinach.
- snarfy 8y agoThis video from the Royal Institute has a lot of good info on the microbiome. https://www.youtube.com/watch?v=-LUuqxQSaFQ https://www.youtube.com/watch?v=-LUuqxQSaFQ
- infimoinfinito 8y agoI don´t agree with the use of the word ~Potential~ It sounds ridiculous, in my opinion, like in a federal good wife´s court, your honor
- justanotherjoe 8y agoAnyone knows if probiotics like yakult may help?
- et-al 8y agoGet yourself some kefir or ayran instead. Yakault is a "pro-biotic" only in the sense that it provides sugar to the bacteria in your body.
- rygxqpbsngav 8y agoSauerkraut helped me get better. I included it in my dinner salads. Careful with store bought fermented foods though which uses vinegar.