4 ms·
Strangely, I've gone cold turkey off of SSRI's and with the exception of Paxil, have never experienced the Brain Zaps or extreme withdrawal symptoms others repo
by aantix 8y ago
Strangely, I've gone cold turkey off of SSRI's and with the exception of Paxil, have never experienced the Brain Zaps or extreme withdrawal symptoms others report. I wonder why it would vary?
Also, sample size=1, CBD oil for me appears to have many of the anti-anxiety affects that the other SSRI's have provided me, with much less side affects. Although, the dosing is all over the map and varies from manufacturer, so that's a challenge. But it does seem to provide me some relief. I just hope I’m not doing long term damage..
- sjg007 8y agoDose dependent maybe? Length of time on the antidepressant?
- MeltySmelty 8y agoBecause not every person has the same brain. Pretty simple.
- SketchySeaBeast 8y agoI took myself off my SSRI's about a decade ago, and I experienced the brain/hands/feet zaps, but none of the other symptoms. I'd been on the medication for about 4 years at that time.
- just1nn 8y agoTry an SNRI. They have more of the "zap" effects when DC'd.
- subcosmos 8y agoThis is my experience too. I think some of this also comes with movement tracking. More of a dopamine/neuropinephrine signaling axis.
- jashpool 8y agoI believe the reason for the variation in discontinuation symptoms between different SSRIs is that half-life of Paxil (paroxetine) is shorter (24h) than that of some of the other drugs in the group such as Prozac (fluoxetine) (2-4 days, and a metabolite is 1-2 weeks.
- mrfusion 8y agoWhat dose for cbd? Does it get expensive?
- aantix 8y agoIt is expensive. Usually 45-60 dollars for a months supply. I’ve used the American Shaman water soluble full-spectrum and Medterra isolate CBD oil. Both were effective for me with a slight preference towards the Medterra isolate. It’s about the most “normal” feeling I’ve ever had. Definitely by far the most effective treatment I’ve had for anxiety, and that’s including the SSRI’s. Probably beats Lexapro because of the near non-existent side effects for me. But again, sample size 1. The /r/cbd group is a good starting place.
- throwaway5d097 8y agoCBD isolate by itself can be a lot cheaper. The cheapest I've found is online from Fully Activated, around $20/g. You should be able to mix your own tinctures with liquid coconut oil, and optionally sunflower lecithin.
- GordonS 8y agoI guess genetics are at play. For example, I have a genetic mutation that means I metabolise tricyclics much faster (and tricyclics block the reabsorption of serotonin and norepinephrine, much like SNRIs). Rate of metabolism would affect peak plasma concentrations and half life. It's quite possible that similar mutations exist that affect SSRI metabolism.