3 ms·
Right. And unless the inactive R-isomer has some negative effect, it's a meaningless change.
by mirimir 8y ago
Right. And unless the inactive R-isomer has some negative effect, it's a meaningless change.
- refurb 8y agoKetamine isomer (S+) induces less drowsiness, less lethargy and less impairment in clustered subjective cognitive capacity than equianalgesic small-dose racemic ketamine. In addition, S(+) ketamine causes less decline in concentration capacity and primary memory [Pfenninger et al. 2002]. The S(+) isomer of ketamine has about twice the analgesic potency of the clinically used racemic mixture. Therefore, the known side effects may be reduced when one half of the usual dose is administered. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910398/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910398/
- mirimir 8y agoThanks. But if S(+) ketamine has been commercially available, even if only illegally, it's not patentable.
- AstralStorm 8y agoNot quite, the specific purification process may or may not be patentable.
- mirimir 8y agoTrue. Process patent. But those are harder to defend in litigation, as I recall.
- AstralStorm 8y agoR isomer is quite active too and similarly, which is why nobody bothered with purified S isomer.