5 ms·

I'm surprised you were able to function the next day with that amount. I recently turned 30, and I definitely cannot drink as much as I used to. I get an allerg

I'm surprised you were able to function the next day with that amount. I recently turned 30, and I definitely cannot drink as much as I used to. I get an allergic response to alcohol, which really sucks because I used to enjoy it. There is a mutation in OPRM1 in certain populations that causes your opiate receptors (particularly mu subtype) to release endorphins when drinking. I've definitely had that happen to me when I used to drink heavily. But that changed when I took LSD-25. While I still drink, it is nowhere near the same level as when I was younger, and I attribute that to my psychedelic experiences. Stay strong.

grogenaut 8y ago
What's the allergic response?
- 0x8BADF00D 8y ago
  Histaminergic. My eyes get watery, throat gets scratchy, nose runny, etc.
- computerex 8y ago
  I am allergic to alcohol too, always have been. Drinking causes my skin to turn bright red, and it makes me feel like I'm on fire. Burning pins and needle all over my body, especially the soles of my feet. It's excruciating, and as a result I don't drink.
protomyth 8y ago
You’d be surprised how much a person can routinely drink and still function. I grew up and now work in a high alcohol abuse area, and some of the folks that were abusing surprised me. Sadly, I’m sure when their body said enough it came as a surprise to them too. Keep safe folks
- busterarm 8y ago
  I spent ages 19-26 essentially spending 100% of my free time 4-6 days a week inside bars. At its worst (at 6 days/week), I was keeping changes of clothes at work, closing the bar, fooling around with someone for a few hours and then going back to work. At 26 my drinking started to trail off severely and I had sort of a breakdown...moved somewhere else for a few years. I don't really know what motivated me to drink like that or to stop. Luckily, I can drink socially without issue and I maybe have 1 or 2. Any drinking (socially) I do is maybe once or twice a month now and I don't spend any time in bars. I have seen a lot of other peoples' lives ruined by drinking though. I'm lucky that the worst I have to deal with is some extra weight and an aversion to going out to drink. Like the parent post says, please keep safe.
- BartBoch 8y ago
  It's important to say that the way of drinking is probably everything. No shots, avoiding sugary mixers, avoiding beer if possible (at least the cheaper ones), never mixing different alcohols (even the same type, but of different brands). The worse you feel the next day after alcohol means the more significant damage you did to your body. If you feel fresh, it says that the damage was almost non-existent (besides liver, which, if you drink a lot of alcohol you should take care separately). Then drinking a lot of water before going to bed will help your body to clean from alcohol. It's all about alcohol-drinking culture. In some countries drinking alcohol 2-4 times a week is normal (as long as you don't drink to get wasted). But I have seen places (for example Ireland), where drinking to get wasted is an ultimate goal 2-4 times a week. That's the problem imo. Better education and public awareness would help a lot.
  - dajohnson89 8y ago
    is there any evidence that mixing alcohols or drinking cheap booze is worse for you?
    - yeahforsureman 8y ago
      No.
    - trevyn 8y ago
      Well, how cheap we talking? :-) https://www.reuters.com/article/us-india-liquor/deaths-mount-to-150-in-indias-second-toxic-liquor-tragedy-this-month-idUSKCN1QD09O https://www.reuters.com/article/us-india-liquor/deaths-mount...
    - BartBoch 8y ago
      Try it, then try drinking only one type of better alcohol. Compare how you feel the next day. That should say a lot. It's rather common knowledge that is not proven scientifically. There has been a lot of talk about it for years in many sport/gym related communities. Those people know how to observe their bodies and reaction.
  - jstarfish 8y ago
tmikaeld 8y ago
I had the same experience, but took hbws seeds (LSA, similar to LSD). Would not have gotten out of it otherwise.. luckily, my allergies also blossoms when taking a drink, reminding me how bad it is.
- k_sh 8y ago
  If you feel like you're having allergic episodes when drinking, you may have some sinus issues lurking!
  - tmikaeld 8y ago
    I'll do a checkup, thanks for pointing this out. I've already tested myself for all types of allergies and other related issues, weird that none of the doctors pointed out sinus issues.
sizzle 8y ago
This is super interesting, as someone with that mutation that gets extra sedated/euphoria from drinking and is predisposed to alcoholism, from a family tree full of alcoholics. What do you think the lsd did to dampen the effects on opiate receptor to release endorphins? I have experimented with naltrexone and it works well to block my opiate receptors when drinking. It just scares me that I'm blocking all euphoria and how I'm messing with neuroplasticity and encoding long term memories... Thoughts?
- knownhoot 8y ago
  similar situation -- have had a lot of success with nal. but now curious about the neuroplasticity you mention. curious if you have any further reading on this. I'm reading Pollan's new book "How to Change your Mind" and it makes me very interested in exploring LSD more for similar addiction purposes.
posterboy 8y ago
LSD is an acid, literally, maybe it just burns the receptors. Non of that experience talk. It's not an opiate anyway but the body can produce neuro transmitters on its own, if you are paradoxically happy about intoxicating yourself. If somehow this pathway is interrupted, I'm not sure that's a good thing. Alcohol in great masses can have the same effect, after all, if the drinking at some point only serves to feel miserable, lacking the joy and done only out of habbit.
- danielbln 8y ago
  You know what else is an acid? DNA.
dajohnson89 8y ago
in my younger years, up till about 26, i could get drunk and show up to work at 9am the next day, ready to go. i’m almost 30 now and i literally can’t drink a single beer without feeling hungover the next morning. if i drink 3 or more, i might as well call in sick. as a result, i just stopped completely. there’s other ways to have fun that don’t make me feel terrible.
- randomsearch 8y ago
  Empathise with that. What other things do you do for fun?
- mutt2016 8y ago
  26 was my year too.. I remember the day vividly where I became a little older. Next hit was at 34.
  - dajohnson89 8y ago
    I can't wait.

grogenaut 8y ago

What's the allergic response?

0x8BADF00D 8y ago
Histaminergic. My eyes get watery, throat gets scratchy, nose runny, etc.
computerex 8y ago
I am allergic to alcohol too, always have been. Drinking causes my skin to turn bright red, and it makes me feel like I'm on fire. Burning pins and needle all over my body, especially the soles of my feet. It's excruciating, and as a result I don't drink.

protomyth 8y ago

You’d be surprised how much a person can routinely drink and still function. I grew up and now work in a high alcohol abuse area, and some of the folks that were abusing surprised me. Sadly, I’m sure when their body said enough it came as a surprise to them too. Keep safe folks

busterarm 8y ago
I spent ages 19-26 essentially spending 100% of my free time 4-6 days a week inside bars. At its worst (at 6 days/week), I was keeping changes of clothes at work, closing the bar, fooling around with someone for a few hours and then going back to work. At 26 my drinking started to trail off severely and I had sort of a breakdown...moved somewhere else for a few years. I don't really know what motivated me to drink like that or to stop. Luckily, I can drink socially without issue and I maybe have 1 or 2. Any drinking (socially) I do is maybe once or twice a month now and I don't spend any time in bars. I have seen a lot of other peoples' lives ruined by drinking though. I'm lucky that the worst I have to deal with is some extra weight and an aversion to going out to drink. Like the parent post says, please keep safe.
BartBoch 8y ago
It's important to say that the way of drinking is probably everything. No shots, avoiding sugary mixers, avoiding beer if possible (at least the cheaper ones), never mixing different alcohols (even the same type, but of different brands). The worse you feel the next day after alcohol means the more significant damage you did to your body. If you feel fresh, it says that the damage was almost non-existent (besides liver, which, if you drink a lot of alcohol you should take care separately). Then drinking a lot of water before going to bed will help your body to clean from alcohol. It's all about alcohol-drinking culture. In some countries drinking alcohol 2-4 times a week is normal (as long as you don't drink to get wasted). But I have seen places (for example Ireland), where drinking to get wasted is an ultimate goal 2-4 times a week. That's the problem imo. Better education and public awareness would help a lot.
- dajohnson89 8y ago
  is there any evidence that mixing alcohols or drinking cheap booze is worse for you?
  - yeahforsureman 8y ago
    No.
  - trevyn 8y ago
    Well, how cheap we talking? :-) https://www.reuters.com/article/us-india-liquor/deaths-mount-to-150-in-indias-second-toxic-liquor-tragedy-this-month-idUSKCN1QD09O https://www.reuters.com/article/us-india-liquor/deaths-mount...
  - BartBoch 8y ago
    Try it, then try drinking only one type of better alcohol. Compare how you feel the next day. That should say a lot. It's rather common knowledge that is not proven scientifically. There has been a lot of talk about it for years in many sport/gym related communities. Those people know how to observe their bodies and reaction.
- jstarfish 8y ago

tmikaeld 8y ago

I had the same experience, but took hbws seeds (LSA, similar to LSD). Would not have gotten out of it otherwise.. luckily, my allergies also blossoms when taking a drink, reminding me how bad it is.

k_sh 8y ago
If you feel like you're having allergic episodes when drinking, you may have some sinus issues lurking!
- tmikaeld 8y ago
  I'll do a checkup, thanks for pointing this out. I've already tested myself for all types of allergies and other related issues, weird that none of the doctors pointed out sinus issues.

sizzle 8y ago

This is super interesting, as someone with that mutation that gets extra sedated/euphoria from drinking and is predisposed to alcoholism, from a family tree full of alcoholics. What do you think the lsd did to dampen the effects on opiate receptor to release endorphins? I have experimented with naltrexone and it works well to block my opiate receptors when drinking. It just scares me that I'm blocking all euphoria and how I'm messing with neuroplasticity and encoding long term memories... Thoughts?

knownhoot 8y ago
similar situation -- have had a lot of success with nal. but now curious about the neuroplasticity you mention. curious if you have any further reading on this. I'm reading Pollan's new book "How to Change your Mind" and it makes me very interested in exploring LSD more for similar addiction purposes.

posterboy 8y ago

LSD is an acid, literally, maybe it just burns the receptors. Non of that experience talk. It's not an opiate anyway but the body can produce neuro transmitters on its own, if you are paradoxically happy about intoxicating yourself. If somehow this pathway is interrupted, I'm not sure that's a good thing. Alcohol in great masses can have the same effect, after all, if the drinking at some point only serves to feel miserable, lacking the joy and done only out of habbit.

danielbln 8y ago
You know what else is an acid? DNA.

dajohnson89 8y ago

in my younger years, up till about 26, i could get drunk and show up to work at 9am the next day, ready to go. i’m almost 30 now and i literally can’t drink a single beer without feeling hungover the next morning. if i drink 3 or more, i might as well call in sick. as a result, i just stopped completely. there’s other ways to have fun that don’t make me feel terrible.

randomsearch 8y ago
Empathise with that. What other things do you do for fun?
mutt2016 8y ago
26 was my year too.. I remember the day vividly where I became a little older. Next hit was at 34.
- dajohnson89 8y ago
  I can't wait.