As usual: it depends... If you're doing prototyping and are working in a Jupyter notebook, sure, go ahead and work on the Pandas-level. Once however you're done

As usual: it depends... If you're doing prototyping and are working in a Jupyter notebook, sure, go ahead and work on the Pandas-level. Once however you're done with prototyping and have settled to a "final_df" (I bet you have something like that in your last notebook cells), maybe you should think transforming some of the "columns" to sql queries (which are VCS-able, sometimes are faster, and most importantly other people can use them too. And instead of 10 people loading 10 different DFs, you can have 10 people querying the same table/view.