I agree "any mice trial" is too strong a statement, and also 4 groups is kind of infeasible. But I do think there is not enough research on how these particular

I agree "any mice trial" is too strong a statement, and also 4 groups is kind of infeasible. But I do think there is not enough research on how these particular inbred mouse strains might bias research. Even the same strain sourced from different companies have produced different results, due to microbiome differences [1]. It's possible that we are way "overfitting" to these particular academic mice [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870873/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870873/