4 ms·
The issue with that approach is that you’d multiply the number of sacrificed animals by 3 (or 4, did you forget a breed?), for limited gains in insight. Your ap
by klmr 8y ago
The issue with that approach is that you’d multiply the number of sacrificed animals by 3 (or 4, did you forget a breed?), for limited gains in insight. Your approach would be a lot more defensible if it didn’t involve killing vastly more animals, and a fairly large increase in research cost. These things are always a balance, and there’s no evidence that always using your approach would be worth it.
- ennisthemennis 8y agoI agree "any mice trial" is too strong a statement, and also 4 groups is kind of infeasible. But I do think there is not enough research on how these particular inbred mouse strains might bias research. Even the same strain sourced from different companies have produced different results, due to microbiome differences [1]. It's possible that we are way "overfitting" to these particular academic mice [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870873/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870873/