Melanoma is definitely due to DNA damage; somatic mutation is the principal cause of all cancer. In this case the cause is either direct damage or damage by fre

Melanoma is definitely due to DNA damage; somatic mutation is the principal cause of all cancer. In this case the cause is either direct damage or damage by free radical byproducts created by UV. UV causes a kind of mutation in DNA called a pyrimidine dimer, where two adjacent bases mutate at once. By far the most common mutation in melanoma (reponsible for 50% of cases) is a CC to TT mutation at position 600 of the gene BRAF.