I'm right handed, and after experiencing some starting RSI issues, I've switched my workplace mouse to the left. I'm using a cheap upright mouse. At home it's r

I'm right handed, and after experiencing some starting RSI issues, I've switched my workplace mouse to the left. I'm using a cheap upright mouse. At home it's right-handed, with a three-button IBM/Lenovo mouse (no scroll wheel). Helped my issues a lot, and I haven't experienced a major difference between UI navigation or even light image manipulation between the two setups. Then again, I'm not a twitch gamer or visual artist, so you might call that an "ambisinister" setup. Only having to move my left arm 10cm at work to get from keyboard to mouse is a nice added benefit, although you'd get the same for a dextrous arrangement if you wouldn't use a full size keyboard.