5 ms·

Is there any reason not to do CGP preemptively?

• aaavl2821 8y ago
  I believe they are sequencing tumor tissue
• yread 8y ago
  Mutations can be divided to germline (~what you inherited, it's part of your normal dna, but it increases likelihood of getting cancer, for example by making dna self repair less effective, think Angelina Jolie) and somatic (random (?) mutations that enable unlimited growth, switch off cell death and so on and are only present in the tumor). There can be multiple mutation groups within a single tumor. Preemptive testing is useful and done for people with history of early cancers in family but obviously can detect only germline mutations. Most of the targeted therapies target somatic mutations. Some hospitals doing genomic testing share their data through AACR GENIE project https://www.aacr.org/Research/Research/Pages/aacr-project-genie.aspx https://www.aacr.org/Research/Research/Pages/aacr-project-ge...
• ed312 8y ago
  There is no harm that I am aware of - but it may not be considered necessary depending on the source. For example, some insurance providers will only reimburse after you're at a certain stage. I can tell you that if I or someone I love was diagnosed, I would get CGP immediately. Potentially avoiding a round of chemo that probably wouldn't even work... that's worth it to me.
• sjg007 8y ago
  Depends on the tumor/cancer type. If it doesn't inform the treatment protocol then it's basically only useful for knowledge. However, more information is always better and useful, especially in the future. So if you can do a CGP you should, or even better get complete sequencing done. But that latter is a 10k cost possibly more. Most cancer centers have a pipeline for treatment and also for research so usually you are in good hands. If a particular CGP is useful then they and the insurance will do it.