i'm trying to learn more about this space as i have a few friends working on building brain-like organoids, converting different types of neural / glial cells t

i'm trying to learn more about this space as i have a few friends working on building brain-like organoids, converting different types of neural / glial cells to other types, etc seems like this stuff is mostly at the basic science stage, with main applications being better disease models (which in neuro is huge). do you have a sense for how far along these are translationally? do the cultured / expanded cells build up lots of mutations? can you induce specific neural cell types, or at least consistently end up with daughter cells that have the same function as their parents? are these processes scalable beyond the quantities needed for this initial work? are there quality methods in place for determining the identity and function of these cells?