To fully address that question you'd probably want to review the meta coverage of the topic. I'm not offering a comprehensive listing but these are two links y

To fully address that question you'd probably want to review the meta coverage of the topic. I'm not offering a comprehensive listing but these are two links you might consider: http://www.readwriteweb.com/start/never-mind-the-valley/ http://www.readwriteweb.com/start/never-mind-the-valley/ http://www.fastcompany.com/1699323/why-you-should-start-a-company-in-raleigh-durham http://www.fastcompany.com/1699323/why-you-should-start-a-co... The key take away (for me) isn't that one city can make or break a company but there are certain considerations to make. Caveat A: if your company success is predicated on being inside of a known echo chamber or circulatory system of talent -- by all means consider SF/NY/etc... Caveat B: if you need to be aligned a specific niche that has no ties to an "NFL city" -- get away as fast as you can to where that niche can best be served with the basics quality of life that will draw the talent and team you desire. SAS software is the largest privately held software company on the planet. Yet... they started not in SF/NY... but... North Carolina? rip needle across the record http://sas.com http://sas.com RightNow is a public software company that was not started in SF/NY... but... Montana? rip needle across the record http://rightnow.com http://rightnow.com There are more. Seriously. Think about it and do the searches. Download Crunchbase and plot it... http://trends.techcrunch.com/ http://trends.techcrunch.com/ Don't take my text for it... Just pick up your head and look around to see a world that doesn't -exclusively- fit in zip codes starting with 941xxx and 112xxx.