It's interesting, I use a kinesis advantage which has a pretty much identical layout and I use the bottom row of keys and thumb 1u thumb cluster keys regularly.

It's interesting, I use a kinesis advantage which has a pretty much identical layout and I use the bottom row of keys and thumb 1u thumb cluster keys regularly. In fact I now vastly prefer the fact that the arrow keys are so close to the home row. That said - the kinesis is curved which probably makes it a lot easier to get your fingers to things?