Given that nicotine has been known to have harmful effects since the first time it was isolated, nearly 200 years ago [1], that is not an unreasonable approach

Given that nicotine has been known to have harmful effects since the first time it was isolated, nearly 200 years ago [1], that is not an unreasonable approach to take. Just because it is being delivered in a slightly different mechanism doesn't mean that the previous research in entirely inapplicable. If I know that banging my head against a brick wall hurts, it is reasonable to assume that banging my head against a wooden wall will also hurt. [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363846/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363846/