This is exactly why I typically have all sorts of prior rejection criterion to trim down my (relatively humble) set of 17 million trial molecules. I don't have

This is exactly why I typically have all sorts of prior rejection criterion to trim down my (relatively humble) set of 17 million trial molecules. I don't have a proper cluster like you-all do. So,'beggars' need to do the easy rejections early (e.g. >12 rotatable bonds? 11 H-bond donors? partition coefficient of 7.3? therefore no further consideration is needed) ADME before an expensive docking.