I think interfaces should be constrained to match the specifications of your input devices and screens. If your users use a mouse, then dense windows with lots

I think interfaces should be constrained to match the specifications of your input devices and screens. If your users use a mouse, then dense windows with lots of check boxes and radio buttons is usable, and probably preferred. If your users might interact with fingers on a tablet or phone, then you need more space around things to make it easier on the user. I've never been a fan of trying to build one interface that works for all systems. It sounds great in theory, but in the end you are left with everything at the level best suited for the least capable system. Same goes for games, by the way. If you see I'm using a mouse and a keyboard, present me a different interface than if I'm using a controller.