4 ms·
I thought the point of the library of molecules used was the supplier (Enamine) has a systematic method of synthesizing the molecules they've listed. It appears
by daddylonglegs 8y ago
I thought the point of the library of molecules used was the supplier (Enamine) has a systematic method of synthesizing the molecules they've listed. It appears that, in practice, they can supply 90% of the molecules they offer, synthesized on demand:
> Of the 589 molecules selected, 549 (93%) were successfully synthesized (Supplementary Table 10 and Supplementary Data 11, 13)
I fully agree your main points.
- fabian2k 8y agoThat's still custom synthesis and not off-the-shelf compounds. No idea how expensive they are in this case.
- daddylonglegs 8y agoAbout $100 apparently: > Over the past decade, Kiev-based Enamine Ltd has innovated an efficient pipeline to produce any of over a billion never-before-made drug-like compounds on demand — at a cost of about $100 per molecule — by combining any of tens of thousands of standard chemical building blocks with one another using over a hundred established chemical reactions.
- justtopost 8y ago'Per molecule' gives no real indication of cost, that appears to be a 'tooling' charge, to design the reaction chain. I doubt $100 will buy you any useful quantity of any research chemical, much less a custom mfg one.