I had some issues that I localized to my right index finger. I apparently click a lot. So my mouse was the main issue. I did end up buying a MS ergonomic key

I had some issues that I localized to my right index finger. I apparently click a lot. So my mouse was the main issue. I did end up buying a MS ergonomic keyboard which I liked, but ultimately, a new mouse is what was the best solution for me. http://www.amazon.com/3M-Ergonomic-Mouse-SMALL-MEDIUM/dp/B00008KWWG http://www.amazon.com/3M-Ergonomic-Mouse-SMALL-MEDIUM/dp/B00... (note it comes in large also). I tried a couple of other designs, but I liked the 3M one the best. It's weird at first, but works well. Thumb for left/right click. I also use the button that's on the stick for scrolling. It's sort of a grab and scroll motion, that works really well. I had to use a utility to implement it: http://www.marcmoini.com/sx_en.html http://www.marcmoini.com/sx_en.html