Rule out absolutely, no, but we can say some kinds of physics are much more likely to be applicable than others. And what matters is applicability by terrestria

Rule out absolutely, no, but we can say some kinds of physics are much more likely to be applicable than others. And what matters is applicability by terrestrial civilization. 'This could be applicable, but only by a civilization capable of building Dyson spheres' is irrelevant to us, because if we get to that point, we will already have made it past the Great Filter.