3 ms·

Its an interesting article.. I have questions! This antibody binds to 'tissue factor' which are present at high levels on the surface of many cancer cells. Are

by clort 8y ago

Its an interesting article.. I have questions! This antibody binds to 'tissue factor' which are present at high levels on the surface of many cancer cells. Are these tissue factor present in significant proportions on other types of cell? (Reading later it suggests that side effects can include nose bleeds which I wonder if that means that nasal tissue also contains this) The figures that they show; obviously it is a small cohort anyway and these people were otherwise considered untreatable but do we know what percentage of (eg) ovarian cancer would otherwise find that their tumors were either shrinking or had stopped growing? It would be important to compare that against the 14% they saw.. The mechanism of action is good, I am not able to say if it is novel (the name they use for the technique relates to an incident ~4000 years ago); do we have leads on other particular circumstances which may be useful to do this? (eg prostate cancer was not affected.. presumably because it has no tissue factor on its surface? could it identifiable by any other means?)

twic 8y ago
> This antibody binds to 'tissue factor' which are present at high levels on the surface of many cancer cells. Are these tissue factor present in significant proportions on other types of cell? Tissue factor is expressed on the surface of the cells adjacent to blood vessels, so it's all over the body. Tissue factor's normal role is to trigger blood coagulation - it reacts with factors in the blood to trigger a coagulation cascade. There is a waterproof layer of endothelial cells between the adjacent TF-bearing cells and the blood itself, so this only happens when a blood vessel is breached by mechanical damage, letting blood come into contact with TF - the resulting coagulation seals the breach. It's a cool system! Although a bit complicated: https://diapharma.com/coagulation/ https://diapharma.com/coagulation/ I had no idea there was a connection between coagulation and cancer, but apparently there is - specifically, it's involved in metastasis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151023/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151023/

by clort 8y ago

twic 8y ago

> This antibody binds to 'tissue factor' which are present at high levels on the surface of many cancer cells. Are these tissue factor present in significant proportions on other types of cell? Tissue factor is expressed on the surface of the cells adjacent to blood vessels, so it's all over the body. Tissue factor's normal role is to trigger blood coagulation - it reacts with factors in the blood to trigger a coagulation cascade. There is a waterproof layer of endothelial cells between the adjacent TF-bearing cells and the blood itself, so this only happens when a blood vessel is breached by mechanical damage, letting blood come into contact with TF - the resulting coagulation seals the breach. It's a cool system! Although a bit complicated: https://diapharma.com/coagulation/ https://diapharma.com/coagulation/ I had no idea there was a connection between coagulation and cancer, but apparently there is - specifically, it's involved in metastasis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151023/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151023/