> Of HPV‐infected patients without evidence of CIN I, 80% cleared the infection, Over 50 percent of new HPV infections are cleared in 6 to 18 months, and 80 to

> Of HPV‐infected patients without evidence of CIN I, 80% cleared the infection, Over 50 percent of new HPV infections are cleared in 6 to 18 months, and 80 to 90 percent will have resolved within two to five years. > while HPV associated with CIN I was eliminated in 83% of patients (P < 0.05). At 12 months, CIN I had regressed in 57% of patients, although this response was not statistically significant. CIN 1 lesions will regress in most women. As an example, a retrospective study of 680 women with biopsy-proven CIN 1 found the following cytology and/or histology results: (1) at six months, 49 percent regressed to negative, 35 percent had persistent CIN 1, and 7 percent had high-grade lesions; (2) at 12 months, among the patients with negative results at six months: 80 percent were negative, 17 percent had low-grade lesions, and 4 percent had high-grade lesions; and (3) at 12 months, among patients with persistent CIN 1 at six months: 50 percent were negative, 46 percent had low-grade lesions, and 4 percent had high-grade lesions (Bansal 2008.) > PDT using 6% 5‐ALA is concluded to be effective in eliminating HPV infection associated or not with CIN I. Doesn’t seem to be much better than the natural course of the untreated disease.