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Two great podcasts to hear David speak about this and some other things. He was on JRE last week. https://www.youtube.com/watch?v=HOTS0HS7aq4 https://www.yout

Two great podcasts to hear David speak about this and some other things. He was on JRE last week. https://www.youtube.com/watch?v=HOTS0HS7aq4 https://www.youtube.com/watch?v=HOTS0HS7aq4 And Peter Attia's Podcast (Peter is probably the Number 1 guy atm when it comes to information on Longevity, The guy is absolutely amazing). https://peterattiamd.com/davidsinclair/ https://peterattiamd.com/davidsinclair/ Both David and Peter have books coming out soon. Can hardly wait.

jcims 8y ago
Heard the JRE podcast, will have to check out Attia's. Tons of good info. Just starting to take a look at this. I've recently had a crash course in biology due to a cancer diagnosis in the family. One of the creepy behaviors of tumors is that they (through mechanisms that I don't understand) signal the body to create new blood vessels to feed tumors as they grow. To combat this, one of the drugs administered during chemo is bevacizumab/Avastin, which has an anti-angiogensis effect and suppresses this behavior in the body (which has some side effects as well). Based on what I'm reading in the article, NMN seems to promote the development of new vessels. I'm curious if this would tend to promote/accelerate the development of tumors. It's of course possible that the two mechanisms would not intersect at all, or even possible that the increased blood flow would reduce senescent cells and other places where things go awry to begin with. Was some other interesting stuff about resveratrol and metformin on the JRE podcast. Need to dig into that too (different family member with Type 1 diabetes, interested in potential theraputic effects of metformin for her as well)
evo_9 8y ago
There is an excellent summary of the JRE here: https://podcastnotes.org/2019/01/30/sinclair https://podcastnotes.org/2019/01/30/sinclair

jcims 8y ago

Heard the JRE podcast, will have to check out Attia's. Tons of good info. Just starting to take a look at this. I've recently had a crash course in biology due to a cancer diagnosis in the family. One of the creepy behaviors of tumors is that they (through mechanisms that I don't understand) signal the body to create new blood vessels to feed tumors as they grow. To combat this, one of the drugs administered during chemo is bevacizumab/Avastin, which has an anti-angiogensis effect and suppresses this behavior in the body (which has some side effects as well). Based on what I'm reading in the article, NMN seems to promote the development of new vessels. I'm curious if this would tend to promote/accelerate the development of tumors. It's of course possible that the two mechanisms would not intersect at all, or even possible that the increased blood flow would reduce senescent cells and other places where things go awry to begin with. Was some other interesting stuff about resveratrol and metformin on the JRE podcast. Need to dig into that too (different family member with Type 1 diabetes, interested in potential theraputic effects of metformin for her as well)

evo_9 8y ago

There is an excellent summary of the JRE here: https://podcastnotes.org/2019/01/30/sinclair https://podcastnotes.org/2019/01/30/sinclair