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Why doesn’t 23 and Me test the whole gene? I can’t imagine it’s because they are ignorant. Is it cost or do they not have all the gene info due to how they

Why doesn’t 23 and Me test the whole gene? I can’t imagine it’s because they are ignorant. Is it cost or do they not have all the gene info due to how they acquire the sample or something else?

cma 8y ago
Cost, but they keep some of the PCRed DNA around and could do it for all their existing client base in the future, for free if selling what they can of the data begins to outweigh the cost.
l33tman 8y ago
23andme only searches for known snips (SNPs, single nucleotide polymorphisms), they don't scan the genome, that is still a fairly costly and slow procedure (although it's radically getting cheaper and cheaper!). https://customercare.23andme.com/hc/en-us/articles/115004459928-Raw-Data-Technical-Details https://customercare.23andme.com/hc/en-us/articles/115004459...
- criddell 8y ago
  > that is still a fairly costly and slow procedure How many zeros are we talking about? Does anybody offer the service?
  - notahacker 8y ago
    Lots of people offer whole genome sequencing. Dante Labs is currently offering it at EUR 259 (no affiliation: I got their mailshot because I bought their lower still Black Friday offer). Typical lab costs are thought to be more in the $1k range, with the assumption that some of these offers are made with the intent of rapidly acquiring a large corpus of anonymised full genome sequences which they hope most of their customers won't opt out of being analysed for commercial scientific research. https://www.dantelabs.com/collections/our-tests/products/whole-genome-sequencing https://www.dantelabs.com/collections/our-tests/products/who...
testplzignore 8y ago
According to https://en.wikipedia.org/wiki/$1,000_genome https://en.wikipedia.org/wiki/$1,000_genome, the cost for whole genome sequencing is now under $1000, with some companies now coming very close to 23andMe's $100-$200 price. I haven't found any info on whether 23andMe is moving in this direction instead of their current methodology.
- chriselles 8y ago
  Veritas Genetics offered 30x coverage full genome sequencing in the lead up to Xmas for $199 to the first 1000 customers. They sold out in about 6 hours. Veritas offered $999 full genome sequencing since 2016. My guess is that we should see a new regular/lower price later this year.

Why doesn’t 23 and Me test the whole gene? I can’t imagine it’s because they are ignorant. Is it cost or do they not have all the gene info due to how they acquire the sample or something else?

cma 8y ago

Cost, but they keep some of the PCRed DNA around and could do it for all their existing client base in the future, for free if selling what they can of the data begins to outweigh the cost.

l33tman 8y ago

23andme only searches for known snips (SNPs, single nucleotide polymorphisms), they don't scan the genome, that is still a fairly costly and slow procedure (although it's radically getting cheaper and cheaper!). https://customercare.23andme.com/hc/en-us/articles/115004459928-Raw-Data-Technical-Details https://customercare.23andme.com/hc/en-us/articles/115004459...

criddell 8y ago
> that is still a fairly costly and slow procedure How many zeros are we talking about? Does anybody offer the service?
- notahacker 8y ago
  Lots of people offer whole genome sequencing. Dante Labs is currently offering it at EUR 259 (no affiliation: I got their mailshot because I bought their lower still Black Friday offer). Typical lab costs are thought to be more in the $1k range, with the assumption that some of these offers are made with the intent of rapidly acquiring a large corpus of anonymised full genome sequences which they hope most of their customers won't opt out of being analysed for commercial scientific research. https://www.dantelabs.com/collections/our-tests/products/whole-genome-sequencing https://www.dantelabs.com/collections/our-tests/products/who...

testplzignore 8y ago

According to https://en.wikipedia.org/wiki/$1,000_genome https://en.wikipedia.org/wiki/$1,000_genome, the cost for whole genome sequencing is now under $1000, with some companies now coming very close to 23andMe's $100-$200 price. I haven't found any info on whether 23andMe is moving in this direction instead of their current methodology.

chriselles 8y ago
Veritas Genetics offered 30x coverage full genome sequencing in the lead up to Xmas for $199 to the first 1000 customers. They sold out in about 6 hours. Veritas offered $999 full genome sequencing since 2016. My guess is that we should see a new regular/lower price later this year.