I would argue that we have no choice and have to master our own genome. Consider that we have entirely removed many of the selective forces that ensured we had

I would argue that we have no choice and have to master our own genome. Consider that we have entirely removed many of the selective forces that ensured we had a healthy gene pool. Take, as a simple example, the selective pressure on any disease that would have killed someone 1000 years ago. Now whatever susceptibility lead to that is not drained from the gene pool, the person is cured at great expense and reproduces furthering the presence of the gene. Don't get me wrong, evolution runs off of death and murder. Replacing it can be amazing, but we almost have no choice.